The Hippocratic Crush 2 will pick up where the first installment left off – Dr. Cheung Yat Kin (Kenneth Ma), now married to Fan Tsz Yu (Tavia Yeung), is faced with new challenges. Yu is pregnant, but being diagnosed with intramedullary spinal cord tumor makes her unfit to bear children. The stubborn Yat Kin insists on carrying the burden for her, and his bullheadedness takes a toll on his relationship with pathology specialist, Lokman (Lawrence Ng ). Yu eventually suffers a miscarriage and also gives up her studies on cardiothoracic surgery. Yat Kin finds it difficult to accept the new changes in his life, but seeing the growth of good friends Yeung Pui Chung (Him Law) and Hung Mei Suet (Mandy Wong) from being inexperienced housemen to becoming trained medical professionals, Yat Kin learns that he must protect himself in order to protect others.